May 7, 2013 ? Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer.
The EPSRC-funded study, published in Biomacromolecules and undertaken by University of Bristol researchers, explored the feasibility of using natural fibres such as silk and cellulose as stem cell scaffolds -- the matrix to which stem cells can cling to as they grow.
Both cellulose and silk are commonly used in textiles but the researchers demonstrated an unexpected use for the two natural polymers when mixed with stem cells. The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult connective tissue stem cells to form into preliminary form of chondrocytes -- the cells that make healthy tissue cartilage -- and secrete extracellular matrix similar to natural cartilage.
Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: "We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors. This new blend can cut the cost for health providers and makes progress towards effective cell-based therapy for cartilage repair a step closer."
Dr Sameer Rahatekar, lead author from the University's Advanced Composite Centre for Innovation and Science (ACCIS), added: "We used ionic liquids for the first time to produce cellulose and silk scaffolds for stem cells differentiation. These liquids are effective in dissolving biopolymers and are environmentally benign compared to traditional solvents used for processing of cellulose and silk."
The teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by University of Bristol, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Nandita Singh, Sameer S. Rahatekar, Krzysztof K. K. Koziol, TH. Sky Ng, Avinash J. Patil, Stephen Mann, Anthony P. Hollander, Wael Kafienah. Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk. Biomacromolecules, 2013; : 130417160122005 DOI: 10.1021/bm301762p
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/GPXvZ83gmjI/130507124811.htm
ncis jenelle evans jenelle evans aapl cispa Katherine Russell Tsarnaev Richie Havens
কোন মন্তব্য নেই:
একটি মন্তব্য পোস্ট করুন